Cystathionine gamma-lyase activity in the cephamycin C producer Streptomyces lactamdurans.

نویسندگان

  • B A Kern
  • E Inamine
چکیده

Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 34 5  شماره 

صفحات  -

تاریخ انتشار 1981